Gradient Bulgaria provides Bio- and Cheminformatics services primarily connected with the proprietary quantum molecular modelling technology developed by Gradient Biomodeling LLC.

Gradient Bulgaria is responsible for the creation and maintenance of specific databases necessary for the quantum molecular modeling methodology, as well as for data integration and annotation of results. The company maintains procedures related with quantum similarity–based molecular modeling including: big data processing and transformation, performance optimizations via parallel calculations, etc. Gradient's team has managed various in-silico- driven R&D projects both in Europe and in the United States.


Tsvetan Mladenov

Tsvetan has more than 15 years of executive experience including as IT Systems Leader of PricewaterhouseCoopers for Central and Eastern Europe. In the last 5 years Mr. Mladenov has been instrumental in building the bioinformatics team capable of addressing Gradient’s specific bio- and chem-informatics needs.

Ivaylo Kirov

Ivaylo provides the necessary software and hardware expertise for the highly demanding quantum calculations and raw data processing. He implements different IT solutions for optimal performance and stability based on .Net, C#, C++, Fortran, SQL, PHP and etc. He holds a Bachelor’s degree in Molecular Biology and a Master’s degree in Bio- and Medical informatics both from Sofia University. Ivaylo has more than 13 years of experience in bio- and pharma software projects in cooperation with some of the major pharma companies like BASF and Bayer.

Lyubomir Nashev, PhD

Lyubomir manages scientific operations at Gradient since 2012. He holds a PhD in Biochemistry and Molecular medicine from University of Berne and he has made a four year post-doctoral training at Pharmacetrum at the University of Basle, Switzerland. He has also worked as bioinfrormatician in Metalife AG, Bulgaria. Lyubomir is in charge of cheminformatic pre- and post-processing of molecular databases and related pharmacological models.

Radoslava Efremova

Radoslava has received degrees from Sofia University and UNWE. She has more than 10 years of experience in finance management. Radoslava is the Gradient Bulgaria’s CFO and has major contribution for the financial success of all completed projects.


Team of experienced software development free lancers on an as-needed basis.

IT and Bioinformatics companies:
- Ontotext of Sirma Group
- Solytron
- Pharmacoidea

Scientists and their students (as interns) from the following scientific and research organisations:
- Institute of Microbiology BAS
- Burgas University
- Plovdiv University
- IMEC, Leiden University


E-mail: gb.tneidarg@ofni

Address: 11, Aksakov Str., Sofia 1000, Bulgaria